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The mortality is higher in subjects with schizophrenia compared to general population. A recent systematic review and meta-analysis showed that the average life expectancy was 64.7 years with an average of 14.5 years of potential life lost. Moreover, this gap concerning life expectancy persisted over time [2]. Natural death is the first cause of mortality in schizophrenia with cardiovascular mortality at the leading cause. The quality of life is significantly lower compared to general population [3]. Depressive symptoms are its strongest factors.

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